General Information

  • ID:  hor002877
  • Uniprot ID:  Q86MA7
  • Protein name:  AREFV-amide
  • Gene name:  NA
  • Organism:  Aplysia californica (California sea hare)
  • Family:  NA
  • Source:  animal
  • Expression:  Expressed abundantly in the abdominal ganglion, much less in the pedal and cerebral ganglia, and rarely in the buccal and pleural ganglia.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AREFV
  • Length:  5(82-86)
  • Propeptide:  MSSQLLICSVFVLFTFGPNSFPSCLAQEQAGNSDATQLSADAKAPESAKDKSGDVQNDGTKSVRSKRDLEIDFGSGDVQKRAREFVGKRAAPPVFQTPLVQDKISGFIPSETESPVIGEFAFPGSVFMDDEEALGAEEEPMDDEDLEFYKRPRQFVGKRGIDDYLLQEKLKDFIEKRPRQFVGKRPRQFVGKRPRQFVGKRPRQFVGKRPRQFVGKRPRQFVGKRPRQFVGKRPRQFVGKRPRQFVGKREADPSF
  • Signal peptide:  MSSQLLICSVFVLFTFGPNS
  • Modification:  T5 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  PRQFV-amide may act as a modulator within the feeding system as well as in other systems of Aplysia.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q86MA7-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002877_AF2.pdbhor002877_ESM.pdb

Physical Information

Mass: 69223 Formula: C28H44N8O8
Absent amino acids: CDGHIKLMNPQSTWY Common amino acids: AEFRV
pI: 6.41 Basic residues: 1
Polar residues: 0 Hydrophobic residues: 3
Hydrophobicity: 16 Boman Index: -1290
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 800 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  12612009
  • Title:  PRQFVamide, a novel pentapeptide identified from the CNS and gut of Aplysia.